OvPlex™ Assay Performance

362 plasma samples from women with ovarian cancer (n=150) and healthy controls (n=212) were used to develop a multivariate classification model incorporating five plasma biomarkers associated with ovarian cancer. Based upon the measurement of these 5 markers, the model calculates the likelihood that a patient has ovarian cancer (i.e. a predicted posterior probability value).

* Edgell et at (2008) Pahe II Biomarker Trial of a Multimarker Diagnostic for Ovarian Cancer, (published Springer: Jan 2010).

The test reports an OvPlex™ value between 0 and 1, in addition to a traditional CA-125 value for reference. At a threshold value of 0.45, OvPlex™ delivers 94% sensitivity and 94% specificity.

Values of greater than 0.45 are indicative of a higher than normal risk of ovarian cancer and it is recommended that the patient be referred to a gynaecologist for further assessment. OvPlex™ values below 0.45 and CA125 < 35 U/ml are indicative of a low risk of ovarian cancer.